Blar i forfatter "Gerits, Nancy"
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Agnoprotein of polyomavirus BK interacts With proliferating cell nuclear antigen and inhibits DNA replication
Gerits, Nancy; Johannessen, Mona; Tümmler, Conny; Walquist, Mari; Kostenko, Sergiy; Snapkov, Igor; van Loon, Barbara; Ferrari, Elena; Hübscher, Ulrich; Moens, Ugo (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-02-01)Background: The human polyomavirus BK expresses a 66 amino-acid peptide referred to as agnoprotein. Though mutants lacking agnoprotein are severely reduced in producing infectious virions, the exact function of this peptide remains incompletely understood. To elucidate the function of agnoprotein, we searched for novel cellular interaction partners. <p>Methods: Yeast-two hybrid assay was performed ... -
BKV Agnoprotein Interacts with alpha-Soluble N-Ethylmaleimide-Sensitive Fusion Attachment Protein, and Negatively Influences Transport of VSVG-EGFP
Johannessen, Mona; Walquist, Mari; Gerits, Nancy; Dragset, Marte Singsås; Spang, Anne; Moens, Ugo (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)The human polyomavirus BK (BKV) infects humans worldwide and establishes a persistent infection in the kidney. The BK virus genome encodes three regulatory proteins, large and small tumor-antigen and the agnoprotein, as well as the capsid proteins VP1 to VP3. Agnoprotein is conserved among BKV, JC virus (JCV) and SV40, and agnoprotein-deficient mutants reveal reduced viral propagation. Studies with ... -
Intensity Dependent Confidence Intervals on Microarray Measurements of Differentially Expressed Genes : A Case Study of the Effect of MK5, FKRP and TAF4 on the Transcriptome
Jakobsen, Kirsti; Van, Belle Werner; Gerits, Nancy; Brox, Vigdis; Van Ghelue, Marijke; Moens, Ugo (Journal article; Tidsskriftartikkel; Peer reviewed, 2007) -
Serine residue 115 of MAPK-activated protein kinase MK5 is crucial for its PKA-regulated nuclear export and biological function.
Kostenko, Sergiy Viktorovich; Shiryaev, Alexey; Gerits, Nancy; Dumitriu, Gianina Aurica; Klenow, Helle Bagterp; Johannessen, Mona; Moens, Ugo (Journal article; Tidsskriftartikkel; Peer reviewed, 2010) -
Transgenic mice expressing constitutive active MAPKAPK5 display gender-dependent differences in exploration and activity
Moens, Ugo; Van Belle, Werner; Gerits, Nancy (Journal article; Tidsskriftartikkel; Peer reviewed, 2007-11-12)Background The mitogen-activated protein kinases, MAPKs for short, constitute cascades of signalling pathways involved in the regulation of several cellular processes that include cell proliferation, differentiation and motility. They also intervene in neurological processes like fear conditioning and memory. Since little remains known about the MAPK-Activated Protein Kinase, MAPKAPK5, we constructed ...